![]() ![]() The association of anti-MOG disease with psychiatric manifestations needs further research. MOG (anti-myelin oligodendrocyte glycoprotein) antibody disease is a group of demyelinating disorders of the central nervous system, in. Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is a newly classified inflammatory demyelinating disease of CNS that shares clinical manifestations with RRMS (7) (8). While the coexistence of psychiatric disease has been studied in other demyelinating diseases, the association with anti-MOG disease is understudied. She received plasmapheresis which resolved her acute symptoms including psychiatric symptoms.Ĭonclusion: Interestingly, MOG expression has been seen in patients with depression and schizophrenia. Second patient also presented with visual symptoms along with auditory hallucinations, anxiety, major depression, and ablutophobia (fear of bathing). This was the start of what would amount to 3 hospital visits and 5 doctor visits with multiple misdiagnoses. Moreover, MOG-antibody disease clinically and radiologically resembles AQP4-antibody neu- romyelitis optica spectrum disorders (NMOSD) and acute demyelinating. Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is the most recently defined inflammatory demyelinating disease of the central. I took her to the Father-Daughter Dance and she became ill 2 days later. At 5 years old, my daughter Isabel was a beautiful, bubbly girl with no health problems. First patient presented with sudden onset of vision loss along with severe anxiety and was treated with intravenous steroids which resolved her symptoms during hospitalization. A Story of ADEM and a New Illness: MOG Antibody-Associated Disease. It has been associated to autoimmune disease with a variety of clinical neurological manifestations including motor and sensory dysfunction, fatigue, and blindness but it's association with psychiatric manifestations has never been reported.Ĭase report: We report two cases of anti-MOG disease presented with psychiatric symptoms to our institution. Background: Myelin oligodendrocyte glycoprotein (MOG) is a glycoprotein that plays an important role in myelination and is exclusively localized in the central nervous system. ![]()
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